Newlyweds Cheney Duvall and Shiloh Irons-Winslow are enjoying an idyllic honeymoon aboard a ship in the West Indies. When a fierce storm interrupts their carefree days, Cheney and Shiloh find themselves on a small island facing a mysterious illness. Quarantining the island and the ship's crew, they work themselves to exhaustion caring for those infected with the highly contagious disease. When Cheney collapses, Shiloh fears the worst.