The Order of Chaos — Michael Reisman

Simon Bloom and his friends Owen and Alysha went from being ordinary middle schoolers to universe-saving superheroes when Simon became the Keeper of The Teacher's Edition of Physics. Using its formulas to control the laws that govern the universe, Simon and company defeated the deadly Sirabetta (twice) and had fun with amazing abilities along the way. Now, with Sirabetta as their captive, Simon, Owen, and Alysha must journey to the Order of Chemistry to remove her powers.

But other villains are hot on their trail, and something mysterious and terrible is happening within the Knowledge Union. Something that even frightens the Narrator and Miss Fanstrom as they watch from afar. With Keepers disappearing and powers diminishing, Simon and his friends rely on their wits -- and some unexpected allies -- as they struggle to save the universe from descending into total chaos or worse, complete and permanent order.