Two years ago, Detective Sami Rizzo narrowly escaped a brush with death at the hands of a serial killer. After apprehending the killer and bringing him to justice, this life-changing event compels her to resign from the police force. In her heart of hearts, however, she struggles with the decision. But a second serial killer -- a well- respected doctor gone astray -- uses his charm to seduce his victims and then performs horrific surgical experiments on them. In a final act of depravity, he scatters their mutilated bodies throughout San Diego County.
Feeling a sense of duty and obligation, Sami Rizzo appeals to the police chief and mayor, and they reinstate her as a homicide investigator. As the body count grows and the killer's experiments become more and more brutal, Sami follows one dead-end lead after another, while trying to deal with a sickly mother and a turbulent relationship with her lover. But then the killer makes a crucial mistake: one of his victims survives. Sami does everything to protect the barely alive victim, but the killer has a different plan…
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