Painkiller Jane — Joe Quesada

Jane Vasko was an undercover police officer attempting to infiltrate a major New York city drug ring. After gaining the trust of dealers, her cover was unknowingly blown and she was forced drugged into a coma. Jane remained in secrecy as a Jane Doe until one day she awoke to a world where nothing was the same. Infused somehow during her fitful sleep with strange powers, Jane has nothing left to lose and a whole lot of people to make pay for what they've done...