A deadly serum that causes anyone it touches to go violently insane has been stolen. Spider-Man must find the culprit before the serum is used to wreak havoc on the city. As if that weren't enough, someone has freed Carnage, the psychotic, super-powered serial killer, from prison--and he's gunning for Spidey!
But even these crises pale in comparison to the revelation that is rocking Spider-Man to his very soul: the return of the Green Goblin, a foe Spidey thought was dead twice over. And the Goblin is determined to drive Spider-Man over the edge...
Two deadly enemies, brought together in an electrifying adventure that could mean the end of the amazing Spider-Man!
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