Octopus Pie: There Are No Stars in Brooklyn — Meredith Gran

What is Octopus Pie?
 
Follow the adventures of two Brooklynites -- Eve, a nerdy acerbic twentysomething and her roommate, Hanna, a long-lost friend who has blossomed into a chronically happy-go-lucky stoner. Crazed childhood rivals, art world hipsters, Eve's meddlesome mom, and boyfriends past and present crowd their odd yet ordinary lives.

In the twilight zone between college and the adult world lies the sardonic, witty, maddening, and sometimes melancholy terrain that Meredith Gran's addictive comic Octopus Pie maps with devastating, drop-dead-funny accuracy.
 
This book collects the first two years of strips, plus bonus material.