Empty Cities of the Full Moon — Howard V. Hendrix

Venturing into a universe different from where his previous novels -- Lightpaths, Standing Wave, and Better Angels -- were set, Howard V. Hendrix tackles one of life's most enduring questions: What does it mean to be human?
In a dramatically altered near-future, the world's newest technology resurrects a plague of apparent global madness that not only destroys ten thousand years of urban civilization, but also creates a world under the sway of the full moon -- and a human race transformed in astonishing ways.